Leucocyte Trafficking: The Role of Fucosyltransferases and Selectins

An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in health and disease. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactions of selectins and their ligands. It has recently become evident that fucosyltransferases are crucial for selectin ligand synthesis, inflammation, and skin homing. This book provides an in-depth overview of the mechanisms of leukocyte trafficking and of the molecular mechanisms of selectin/selectin ligand interactions and discusses options for pharmacological intervention to treat inflammatory diseases.Additional ISBNs9783540401124, 9783662053997Leucocyte Trafficking: The Role of Fucosyltransferases and Selectins 1st Edition is written by A. Hamann;?Khusru Asadullah;?A. Schottelius and published by Springer. ISBNs for Leucocyte Trafficking are 9783662053973, 3662053977 and the print ISBNs are 9783662053973, 3662053977. Additional ISBNs include 9783540401124, 9783662053997.