Endocrine Manifestations of Systemic Autoimmune Diseases

.This book is one of the first to evaluate the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements and focuses on the importance of steroidal hormones in the pathogenesis and therapeutic management of the autoimmune rheumatic diseases. In particular, the chapters analyze the mechanisms of action and the involvement of adrenal steroids (glucocorticoids) in the neuroendocrine immune system, including effects on the elderly.The perturbations of the HPA axis as a source of altered steroidal synthesis will be discussed and related to some interesting pathological conditions that commonly complicate the autoimmune rheumatic diseases such as psychosis or fibromyalgia. Concerning the role of gonadal steroids (sex hormones), several chapters will discuss clinical and epidemiological evidences of their role, as well as their effects as risk factors in autoimmune rheumatic diseases, including a section on pediatrics.*The premier issue evaluating the role of steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements*Documents the latest research and indicate recent and coming new therapeutic-biological approaches to the therapy*The book will present therapeutic perspectives concerning the new glucocorticoids, and the effects of biological drugs on their synthesisEndocrine Manifestations of Systemic Autoimmune Diseases is written by Asherson, Ronald and published by Elsevier Science. ISBNs for Endocrine Manifestations of Systemic Autoimmune Diseases are 9780444531728. Additional ISBNs include 9780120884940, 9780080570303.