Torsades de Pointes

Over the past 25-30 years, deaths due to Torsades de Pointes (Td P) have resulted in numerous drugs being withdrawn from the market.However, nearly 200 drugs that may prolong the QT interval and cause Td P remain available. A number of drugs with the potential to cause Td P are among the top 200 most prescribed drugs in the US, whilst new information regarding Td P is emerging rapidly. The purpose of this book is to provide a comprehensive source of information on the topic of torsades de pointes (Td P), which is a life-threatening polymorphic ventricular tachyarrhythmia associated with QT interval prolongation on the electrocardiogram (ECG).Torsades de Pointes provides a detailed, up-to-date and emerging information related to the epidemiology, drug culprits, mechanisms, risk factors, and methods of prevention and management of the life-threatening polymorphic ventricular tachycardia, also known as torsades de pointes. The book contains current knowledge, incorporating recent and cutting-edge advances in understanding of topics including inherited channelopathies and congenital LQTS; drugs that cause QT interval prolongation and Td P; non-drug causes of acquired QT interval prolongation and Td P; epidemiology of inherited and acquired Td P; morbidity and mortality associated with Td P, particularly in association with specific antimicrobials, antidepressants and antipsychotics, and methadone; cellular and molecular mechanisms of Td P, traditional and emerging risk factors for Td P; methods of prevention and risk reduction for Td P; and clinical management of patients with Td P.This book is an essential reference for both clinicians and researchers � providing guidance for clinicians who care for patients receiving QT interval-prolonging drugs, as well as cutting edge information for scientists and investigators conducting research in the area.Up-to-date information on Td P associated with inherited channelopathies and the multiple forms of congenital LQTSIncludes a wealth of new information emerging regarding Td P, including newly-described risk factors and cellular and molecular mechanisms, contributions of genetic polymorphisms to drug-induced Td P, methods of quantification of risk, and methods of risk reduction, including clinical decision support Contains information on nearly 200 commonly used drugs that have the potential to cause torsades de pointes, including antimicrobials, antipsychotics, antidepressants, antiarrhythmic agents, methadone, and many others An essential reference for clinicians and researchers � provides guidance for clinicians who care for patients receiving QT interval-prolonging drugs, as well as cutting edge information for scientists and investigators conducting research in the area Torsades de Pointes and published by Academic Press. ISBNs for Torsades de Pointes are 9780128214619, 0128214619 and the print ISBNs are 9780128214466, 0128214465.